Detalhe da pesquisa
1.
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 560(7717): 192-197, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30046105
2.
Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 619(7970): E48, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37402863
3.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc Natl Acad Sci U S A
; 116(19): 9318-9323, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962368
4.
Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of Leishmania infection.
Front Trop Dis
; 32023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36818551
5.
Short-course combination treatment for experimental chronic Chagas disease.
Sci Transl Med
; 15(726): eadg8105, 2023 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38091410
6.
Potent antimalarial 4-pyridones with improved physico-chemical properties.
Bioorg Med Chem Lett
; 21(18): 5214-8, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21824778
7.
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
J Med Chem
; 64(9): 5905-5930, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33904304
8.
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity.
J Med Chem
; 63(17): 9523-9539, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32663005
9.
Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis.
RSC Med Chem
; 11(10): 1168-1177, 2020 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479621
10.
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis.
J Med Chem
; 62(3): 1180-1202, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30570265
11.
Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.
J Med Chem
; 51(9): 2845-52, 2008 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18396855
12.
Metabolic Clustering Analysis as a Strategy for Compound Selection in the Drug Discovery Pipeline for Leishmaniasis.
ACS Chem Biol
; 13(5): 1361-1369, 2018 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29671577
13.
Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform.
Sci Rep
; 8(1): 3938, 2018 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29500420
14.
Synthesis and Structure-Activity Relationships of the Novel Antimalarials 5-Pyridinyl-4(1 H)-Pyridones.
J Med Chem
; 61(8): 3422-3435, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29589932
15.
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.
J Med Chem
; 60(17): 7284-7299, 2017 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28844141
16.
New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.
Sci Rep
; 5: 8771, 2015 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25740547
17.
Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1.
Future Med Chem
; 4(18): 2311-23, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23234553
18.
Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series.
J Med Chem
; 53(16): 6129-52, 2010 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20672841
19.
Antifungal sordarins. Synthesis and structure-activity relationships of 3',4'-fused dioxolane and dioxane derivatives.
Bioorg Med Chem Lett
; 12(2): 121-4, 2002 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-11755335
20.
Antifungal Sordarins. Part 4: synthesis and structure--activity relationships of 3',4'-fused alkyl-tetrahydrofuran derivatives.
Bioorg Med Chem Lett
; 12(13): 1697-700, 2002 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-12067540